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13073 details
Primary information
ID13073
Uniprot IDP01364
DescriptionAbdominal ganglion neuropeptide R3-14 [Cleaved into- Histidine-rich basic peptide (HRBP); Peptide I; Peptide II]
OrganismAplysia californica
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Heterobranchia; Euthyneura; Tectipleura; Aplysiida (sea hares); Aplysioidea; Aplysiidae; Aplysia; Aplysia californica (California sea hare)
Subcellular LocationSecreted
Developmental StageNA
SimilarityNA
Tissue SpecificityNeurons R3-R14. A cluster of 12 giant neurons located on the right side of the abdominal ganglion.
Post Translational ModificationThe partial formation of pyroglutamate from N-terminal glutamic acid in peptides isolated from single cells is detected by mass spectrometry (PubMed-9930740). There are indications this modification d
FunctionHRBP is a myoactive peptide that excites Aplysia heart and enhances gut motility in vitro.
Length108
Molecular Weight12
NameAbdominal ganglion neuropeptide R3-14
SequenceQVAQMHVWRAVNHDRNHGTGSGRHGRFLIRNRYRYGGGHLSDA
Sequence map1032
PDB ID6194901; 6474178; 2573895; 3549995; 9930740
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA