| Primary information |
|---|
| ID | 13062 |
| Uniprot ID | P40753 |
| Description | Natriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into- Brain natriuretic peptide 45 (5 kDa cardiac natriuretic peptide) (BNP(77-121)) (Brain natriuretic peptide) (BNP)] |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse) |
| Subcellular Location | [Brain natriuretic peptide 45]- Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the natriuretic peptide family. |
| Tissue Specificity | [Brain natriuretic peptide 45]- Expressed abundantly in the ventricle; and in a lesser extent in the atrium (at protein level). |
| Post Translational Modification | The precursor molecule is proteolytically cleaved by the endoprotease Furin to produce brain natriuretic peptide 45. May undergo further proteolytic cleavage by various proteases such as DPP4; MME and |
| Function | [Brain natriuretic peptide 45]- Cardiac hormone that plays a key role in mediating cardio-renal homeostasis |
| Length | 121 |
| Molecular Weight | 13 |
| Name | Natriuretic peptides B |
| Sequence | YPLGSPSQSPEQFKMQKLLELIREKSEEMAQRQLLKDQGLTKEHPKRVLRSQGSTLRVQQRPQNSKVTHISSCFGHKIDRIGSVSRLGCNALKLL |
| Sequence map | 2280 |
| PDB ID | 8182124; 8097440; 15489334; 10737768 |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|