Detailed description page of Hmrbase2

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13057 details
Primary information
ID13057
Uniprot IDP0DJ94
DescriptionExendin-1 (Helospectin-1) (VIP-like 1) [Cleaved into- Exendin-1b (Helospectin-2)]
OrganismHeloderma horridum horridum
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria (diapsids); Lepidosauria (lepidosaurs); Squamata (squamates); Bifurcata (split-tongued squamates); Unidentata; Episquamata; Toxicofera; Anguimorpha (anguimorph lizards); Neoanguimorpha (New World anguimorph lizards); Helodermatidae (beaded lizards); Heloderma;
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the glucagon family.
Tissue SpecificityExpressed by the venom gland.
Post Translational ModificationO-linked glycan consists of Hex-HexNAc saccharide.
FunctionO-linked and free exendin-1 and exendin-1b have vasoactive intestinal peptide(VIP)/secretin-like biological activities. They interact with rat and human VIP receptors 1 (VIPR1) and 2 (VIPR2); with the highest affinity for the human VIPR2. They induce hypotension that is mediated by relaxation of cardiac smooth muscle.
Length38
Molecular Weight4
NameExendin-1
SequenceHSDATFTAEYSKLLAKLALQKYLESILGSSTSPRPPS
Sequence map888
PDB ID10880980; 9928018; 15003357; 19837656
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA