Primary information |
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ID | 13057 |
Uniprot ID | P0DJ94 |
Description | Exendin-1 (Helospectin-1) (VIP-like 1) [Cleaved into- Exendin-1b (Helospectin-2)] |
Organism | Heloderma horridum horridum |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria (diapsids); Lepidosauria (lepidosaurs); Squamata (squamates); Bifurcata (split-tongued squamates); Unidentata; Episquamata; Toxicofera; Anguimorpha (anguimorph lizards); Neoanguimorpha (New World anguimorph lizards); Helodermatidae (beaded lizards); Heloderma; |
Subcellular Location | Secreted |
Developmental Stage | NA |
Similarity | Belongs to the glucagon family. |
Tissue Specificity | Expressed by the venom gland. |
Post Translational Modification | O-linked glycan consists of Hex-HexNAc saccharide. |
Function | O-linked and free exendin-1 and exendin-1b have vasoactive intestinal peptide(VIP)/secretin-like biological activities. They interact with rat and human VIP receptors 1 (VIPR1) and 2 (VIPR2); with the highest affinity for the human VIPR2. They induce hypotension that is mediated by relaxation of cardiac smooth muscle. |
Length | 38 |
Molecular Weight | 4 |
Name | Exendin-1 |
Sequence | HSDATFTAEYSKLLAKLALQKYLESILGSSTSPRPPS |
Sequence map | 888 |
PDB ID | 10880980; 9928018; 15003357; 19837656 |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
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