| Primary information |
|---|
| ID | 13041 |
| Uniprot ID | P22388 |
| Description | Endothelin-1 (ET-1) (Preproendothelin-1) (PPET1) [Cleaved into- Big endothelin-1] |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the endothelin/sarafotoxin family. |
| Tissue Specificity | NA |
| Post Translational Modification | NA |
| Function | Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B; BCAR1; BCAR3 and; GTPases RAP1 and RHOA cascade in glomerular mesangial cells. |
| Length | 202 |
| Molecular Weight | 23 |
| Name | Endothelin-1 |
| Sequence | CSCSSLMDKECVYFCHLDIIW |
| Sequence map | 504 |
| PDB ID | 1840483; 2039460; 26479776 |
| Drugpedia | 3CMH;6CMH; |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|