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13032 details
Primary information
ID13032
Uniprot IDP05059
DescriptionChromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into- Vasostatin-1; Chromofungin; Chromostatin; Chromacin; Pancreastatin; WE-14; Catestatin; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor]
OrganismBos taurus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos (oxen; cattle); Bos taurus (Bovine)
Subcellular Location[Serpinin]- Secreted
Developmental StageNA
SimilarityBelongs to the chromogranin/secretogranin protein family.
Tissue SpecificityHighest concentration of GE-25 found in adrenal medulla with lower levels present in the pituitary; the intestinal mucosa and the pancreas. Also found in the brain.
Post Translational ModificationIn secretory granules; is attacked at both N- and C-terminal sides by proteolytic enzymes generating numerous peptides of various activities. Proteolytic processing can give rise to additional longer
Function[Pancreastatin]- Strongly inhibits glucose induced insulin release from the pancreas.
Length449
Molecular Weight50
NameChromogranin-A
SequenceSDEDSDGDRPQASPGLGPGP
Sequence map480
PDB ID1779968; 3755681; 3018587; 3474638; 9074643; 12795588; 1986917; 2387861; 8243650; 1996343;
Drugpedia1CFK;1N2Y;
ReceptorNA
DomainNA
Pharmaceutical UseNA