Detailed description page of Hmrbase2

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13019 details
Primary information
ID13019
Uniprot IDQ16568
DescriptionCocaine- and amphetamine-regulated transcript protein [Cleaved into- CART(1-39); CART(42-89)]
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the CART family.
Tissue SpecificityHypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus; in the external zone of the median eminence; and also found in terminals in the periventricular part of the paraventric
Post Translational ModificationNA
FunctionSatiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.
Length116
Molecular Weight12
NameCocaine- and amphetamine-regulated transcript protein
SequenceVPIYEKKYGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLKCL
Sequence map1152
PDB ID8647455; 15489334; 15340161; 9590691; 11478874; 10905499; 11522684
Drugpedia1HY9;
ReceptorNA
DomainNA
Pharmaceutical UseNA