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13006 details
Primary information
ID13006
Uniprot IDP10645
DescriptionChromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into- Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor]
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular Location[Serpinin]- Secreted
Developmental StageNA
SimilarityBelongs to the chromogranin/secretogranin protein family.
Tissue SpecificityGE-25 is found in the brain.
Post Translational ModificationSulfated on tyrosine residues and/or contains sulfated glycans.; O-glycosylated with core 1 or possibly core 8 glycans.
Function[Pancreastatin]- Strongly inhibits glucose induced insulin release from the pancreas.; [Catestatin]- Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist
Length457
Molecular Weight50
NameChromogranin-A
SequenceGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRR
Sequence map1056
PDB ID2445752; 3403545; 8120054; 14702039; 12508121; 15489334; 3704195; 2165909; 2830133; 1577173
Drugpedia1LV4;6R2X;
ReceptorNA
DomainNA
Pharmaceutical UseNA