| Primary information |
|---|
| ID | 12997 |
| Uniprot ID | P01019 |
| Description | Angiotensinogen (Serpin A8) [Cleaved into- Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (A |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the serpin family. |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Post Translational Modification | Beta-decarboxylation of Asp-34 in angiotensin-2; by mononuclear leukocytes produces alanine. The resulting peptide form; angiotensin-A; has the same affinity for the AT1 receptor as angiotensin-2; but |
| Function | Essential component of the renin-angiotensin system (RAS); a potent regulator of blood pressure; body fluid and electrolyte homeostasis.; [Angiotensin-2]- acts directly on vascular smooth muscle as a potent vasoconstrictor; affects cardiac contractility and heart rate through its action on the sympathetic nervous system; and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.; [Angiotensin-3]- stimulates aldosterone release.; [Angiotensin 1-7]- is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets. |
| Length | 485 |
| Molecular Weight | 53 |
| Name | Angiotensinogen |
| Sequence | DRVYIHPFHL |
| Sequence map | 240 |
| PDB ID | 6089875; 2924688; 1692023; 15489334; 2885106; 3579322; 7259779; 7539791; 4300938; 3934016; |
| Drugpedia | 1N9U;1N9V;2JP8;2WXW;2X0B;3CK0;3WOO;3WOR;4AA1;4APH; |
| Receptor | P30556; P50052; P04201; P30556 |
| Domain | NA |
| Pharmaceutical Use | NA
|