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12993 details
Primary information
ID12993
Uniprot IDP01019
DescriptionAngiotensinogen (Serpin A8) [Cleaved into- Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (A
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the serpin family.
Tissue SpecificityExpressed by the liver and secreted in plasma.
Post Translational ModificationBeta-decarboxylation of Asp-34 in angiotensin-2; by mononuclear leukocytes produces alanine. The resulting peptide form; angiotensin-A; has the same affinity for the AT1 receptor as angiotensin-2; but
FunctionEssential component of the renin-angiotensin system (RAS); a potent regulator of blood pressure; body fluid and electrolyte homeostasis.; [Angiotensin-2]- acts directly on vascular smooth muscle as a potent vasoconstrictor; affects cardiac contractility and heart rate through its action on the sympathetic nervous system; and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.; [Angiotensin-3]- stimulates aldosterone release.; [Angiotensin 1-7]- is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
Length485
Molecular Weight53
NameAngiotensinogen
SequenceDRVY
Sequence map96
PDB ID6089875; 2924688; 1692023; 15489334; 2885106; 3579322; 7259779; 7539791; 4300938; 3934016;
Drugpedia1N9U;1N9V;2JP8;2WXW;2X0B;3CK0;3WOO;3WOR;4AA1;4APH;
ReceptorP30556; P50052; P04201; P30556
DomainNA
Pharmaceutical UseNA