| Primary information |
|---|
| ID | 12972 |
| Uniprot ID | P81172 |
| Description | Hepcidin (Liver-expressed antimicrobial peptide 1) (LEAP-1) (Putative liver tumor regressor) (PLTR) [Cleaved into- Hepcidin-25 (Hepc25); Hepcidin-20 (Hepc20)] |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the hepcidin family. |
| Tissue Specificity | Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung; tonsils; salivary gland; trachea; prostate gland; adrenal gland and thyroid gland. Secreted into the urine an |
| Post Translational Modification | NA |
| Function | Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1; leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma |
| Length | 84 |
| Molecular Weight | 9 |
| Name | Hepcidin |
| Sequence | ICIFCCGCCHRSKCGMCCKT |
| Sequence map | 480 |
| PDB ID | 11113131; 11034317; 12975309; 15057824; 15489334; 12010514; 15124018; 22306005; 22682227; 2 |
| Drugpedia | 1M4E;1M4F;2KEF;3H0T;4QAE;6WBV; |
| Receptor | Q9NP59 |
| Domain | NA |
| Pharmaceutical Use | NA
|