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12965 details
Primary information
ID12965
Uniprot IDP04404
DescriptionChromogranin-A (CgA) [Cleaved into- Pancreastatin; Parastatin; WE-14; Catestatin; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] (Fragment)
OrganismSus scrofa
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Suina; Suidae (pigs); Sus; Sus scrofa (Pig)
Subcellular Location[Serpinin]- Secreted
Developmental StageNA
SimilarityBelongs to the chromogranin/secretogranin protein family.
Tissue SpecificityNA
Post Translational ModificationO-glycosylated.; Parathyroid CHGA is sulfated on tyrosine residues; whereas adrenal CHGA seems to be mainly sulfated on oligosaccharide residues.
Function[Pancreastatin]- Strongly inhibits glucose induced insulin release from the pancreas.; [Parastatin]- Inhibits low calcium-stimulated parathyroid cell secretion.; [Catestatin]- Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration; degranulation and production of cytokines and chemokines.
Length446
Molecular Weight49
NameChromogranin-A
SequenceGWPQAPAMDGAGKTGAEEAQPPEGKGAREHSRQEEEEETAGAPQGLFRG
Sequence map1176
PDB ID2834189; 3537810; 8344192; 2105940
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA