Detailed description page of Hmrbase2

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12964 details
Primary information
ID12964
Uniprot IDQ76IQ4
DescriptionGhrelin [Cleaved into- Ghrelin-23; Ghrelin-24]
OrganismOncorhynchus mykiss
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Euteleosteomorpha; Protacanthopterygii; Salmoniformes (salmons and trouts); Salmonidae (salmonids); Salmoninae (trouts; salmons & chars); Oncorhynchus; Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the motilin family.
Tissue SpecificityHighest levels in the stomach. Moderate levels in the brain; hypothalamus and intestinal tracts.
Post Translational ModificationO-octanoylation or O-decanoylation is essential for activity. The O-decanoylated forms differ in the length of the carbon backbone of the carboxylic acid forming an ester bond with Ser-29. The majorit
FunctionLigand for growth hormone secretagogue receptor type 1 (GHSR). Has an appetite-stimulating effect; induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Induces the release of growth hormone from the pituitary.
Length111
Molecular Weight12
NameGhrelin
SequenceGSSFLSPSQKPQVRQGKGKPPRVG
Sequence map576
PDB ID12970156
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA