| Primary information |
|---|
| ID | 12962 |
| Uniprot ID | Q90W22 |
| Description | Ghrelin [Cleaved into- Ghrelin-27; Ghrelin-28] |
| Organism | Lithobates catesbeianus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae (riparian frogs); Lithobates; Lithobates catesbeianus (American bullfrog) (Rana catesbeiana) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | High levels in stomach. Moderate levels in small intestine; pancreas and testis. Low levels in heart; lung and gall bladder. |
| Post Translational Modification | O-octanoylation or O-decanoylation is essential for activity. The O-decanoylated form ghrelin-27-C10 differs in the length of the carbon backbone of the carboxylic acid bound to Thr-27. 33% of frog gh |
| Function | Ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect; induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. |
| Length | 114 |
| Molecular Weight | 12 |
| Name | Ghrelin |
| Sequence | GLTFLSPADMQKIAERQSQNKLRHGNMN |
| Sequence map | 672 |
| PDB ID | 11546772 |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|