| Primary information |
|---|
| ID | 12919 |
| Uniprot ID | O00230 |
| Description | Cortistatin [Cleaved into- Cortistatin-29; Cortistatin-17] |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the somatostatin family. |
| Tissue Specificity | Expressed in a subset of GABAergic cells in the cortex and hippocampus. |
| Post Translational Modification | NA |
| Function | Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs. |
| Length | 105 |
| Molecular Weight | 11 |
| Name | Cortistatin |
| Sequence | DRMPCRNFFWKTFSSCK |
| Sequence map | 408 |
| PDB ID | 9125122; 9205124; 16710414; 15489334; 12975309 |
| Drugpedia | NA |
| Receptor | Q92847-1; Q96LB1; P30872; P30874; P32745; P31391; P35346 |
| Domain | NA |
| Pharmaceutical Use | NA
|