| Primary information |
|---|
| ID | 12899 |
| Uniprot ID | P11859 |
| Description | Angiotensinogen (Serpin A8) [Cleaved into- Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (A |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the serpin family. |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Post Translational Modification | In response to low blood pressure; the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide t |
| Function | Essential component of the renin-angiotensin system (RAS); a potent regulator of blood pressure; body fluid and electrolyte homeostasis.; [Angiotensin-2]- acts directly on vascular smooth muscle as a potent vasoconstrictor; affects cardiac contractility and heart rate through its action on the sympathetic nervous system; and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. |
| Length | 477 |
| Molecular Weight | 51 |
| Name | Angiotensinogen |
| Sequence | DRVYIHPFH |
| Sequence map | 216 |
| PDB ID | 3397061; 12829792; 18026570; 21183079; 20927107 |
| Drugpedia | 2WXX;2WXY;2WY0; |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
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