Detailed description page of Hmrbase2

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12897 details
Primary information
ID12897
Uniprot IDP11859
DescriptionAngiotensinogen (Serpin A8) [Cleaved into- Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (A
OrganismMus musculus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the serpin family.
Tissue SpecificityExpressed by the liver and secreted in plasma.
Post Translational ModificationIn response to low blood pressure; the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide t
FunctionEssential component of the renin-angiotensin system (RAS); a potent regulator of blood pressure; body fluid and electrolyte homeostasis.; [Angiotensin-2]- acts directly on vascular smooth muscle as a potent vasoconstrictor; affects cardiac contractility and heart rate through its action on the sympathetic nervous system; and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
Length477
Molecular Weight51
NameAngiotensinogen
SequenceDRVYI
Sequence map120
PDB ID3397061; 12829792; 18026570; 21183079; 20927107
Drugpedia2WXX;2WXY;2WY0;
ReceptorNA
DomainNA
Pharmaceutical UseNA