Detailed description page of Hmrbase2

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12893 details
Primary information
ID12893
Uniprot IDP13204
DescriptionNatriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into- Aldosterone secretion inhibitory factor (ASIF); Brain natriuretic peptide 26 (BNP-26); Brain natriuretic peptide 29 (BNP-29)]
OrganismBos taurus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos (oxen; cattle); Bos taurus (Bovine)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the natriuretic peptide family.
Tissue SpecificityNA
Post Translational ModificationThe precursor molecule is proteolytically cleaved; possibly by FURIN or CORIN; to produce the active peptide. May undergo further proteolytic cleavage by various proteases such as DPP4; MME and possib
FunctionCardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP; which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis; diuresis; vasorelaxation; and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.
Length129
Molecular Weight14
NameNatriuretic peptides B
SequenceDSGCFGRRLDRIGSLSGLGCNVLRRY
Sequence map624
PDB ID19393038; 2532709; 2537187
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA