| Primary information |
|---|
| ID | 12892 |
| Uniprot ID | P13204 |
| Description | Natriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into- Aldosterone secretion inhibitory factor (ASIF); Brain natriuretic peptide 26 (BNP-26); Brain natriuretic peptide 29 (BNP-29)] |
| Organism | Bos taurus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos (oxen; cattle); Bos taurus (Bovine) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the natriuretic peptide family. |
| Tissue Specificity | NA |
| Post Translational Modification | The precursor molecule is proteolytically cleaved; possibly by FURIN or CORIN; to produce the active peptide. May undergo further proteolytic cleavage by various proteases such as DPP4; MME and possib |
| Function | Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP; which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis; diuresis; vasorelaxation; and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3. |
| Length | 129 |
| Molecular Weight | 14 |
| Name | Natriuretic peptides B |
| Sequence | ALRGPKMMRDSGCFGRRLDRIGSLSGLGCNVLRRY |
| Sequence map | 840 |
| PDB ID | 19393038; 2532709; 2537187 |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|