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12878 details
Primary information
ID12878
Uniprot IDP20156
DescriptionNeurosecretory protein VGF (VGF8a protein) [Cleaved into- VGF(24-63); VGF(180-194); VGF(375-407); Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-11; VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-30; VGF-derived peptide TLQ
OrganismRattus norvegicus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat)
Subcellular Location[Neurosecretory protein VGF]- Secreted
Developmental StageNA
SimilarityNA
Tissue SpecificityCentral and peripheral nervous systems; synthesized exclusively in neuronal and neuroendocrine cells. VGF and several of the derived peptides are present in the brain.
Post Translational ModificationMultiple peptides are derived from VGF; with activities in synaptic plasticity; antidepression; penile erection; autonomic activation; and increases in energy expenditure.
Function[Neurosecretory protein VGF]- Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner
Length617
Molecular Weight68
NameNeurosecretory protein VGF
SequenceAPPGRSDVYPPPLGSEHNGQVAEDAVSRPKDDSVPEVRAA
Sequence map960
PDB ID2676516; 2017159; 1377233; 7595538; 12065665; 16983076; 19164277; 19466987; 19194657; 20551
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA