| Primary information |
|---|
| ID | 12874 |
| Uniprot ID | P20156 |
| Description | Neurosecretory protein VGF (VGF8a protein) [Cleaved into- VGF(24-63); VGF(180-194); VGF(375-407); Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-11; VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-30; VGF-derived peptide TLQ |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat) |
| Subcellular Location | [Neurosecretory protein VGF]- Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Central and peripheral nervous systems; synthesized exclusively in neuronal and neuroendocrine cells. VGF and several of the derived peptides are present in the brain. |
| Post Translational Modification | Multiple peptides are derived from VGF; with activities in synaptic plasticity; antidepression; penile erection; autonomic activation; and increases in energy expenditure. |
| Function | [Neurosecretory protein VGF]- Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner |
| Length | 617 |
| Molecular Weight | 68 |
| Name | Neurosecretory protein VGF |
| Sequence | QAEATRQAAAQEERLADLASDLLLQYLLQGSGARQRDLG |
| Sequence map | 912 |
| PDB ID | 2676516; 2017159; 1377233; 7595538; 12065665; 16983076; 19164277; 19466987; 19194657; 20551 |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|