| Primary information |
|---|
| ID | 12873 |
| Uniprot ID | O15240 |
| Description | Neurosecretory protein VGF [Cleaved into- Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | [Neurosecretory protein VGF]- Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Central and peripheral nervous systems; synthesized exclusively in neuronal and neuroendocrine cells. |
| Post Translational Modification | Multiple peptides are derived from VGF; with activities in synaptic plasticity; antidepression; penile erection; autonomic activation; and increases in energy expenditure. |
| Function | [Neurosecretory protein VGF]- Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner. VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning; memory; depression and chronic pain. |
| Length | 615 |
| Molecular Weight | 67 |
| Name | Neurosecretory protein VGF |
| Sequence | TLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENYIEHVLLRRP |
| Sequence map | 1488 |
| PDB ID | 9344675; 12853948; 15489334; 23250050; 19194657; 26091039; 28934328 |
| Drugpedia | 7D13;7D16; |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|