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12849 details
Primary information
ID12849
Uniprot IDP01284
DescriptionVIP peptides [Cleaved into- Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)] (Fragment)
OrganismSus scrofa
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Suina; Suidae (pigs); Sus; Sus scrofa (Pig)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the glucagon family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionVIP causes vasodilation; lowers arterial blood pressure; stimulates myocardial contractility; increases glycogenolysis and relaxes the smooth muscle of trachea; stomach and gall bladder.; PHM-27 is a potent agonist of the calcitonin receptor CALCR; with similar efficacy as calcitonin. PHI also causes vasodilation.
Length75
Molecular Weight8
NameVIP peptides
SequenceHADGVFTSDFSRLLGQLSAKKYLESLI
Sequence map648
PDB ID6947244; 1329741; 2843830; 4829446; 4854585
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA