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12807 details
Primary information
ID12807
Uniprot IDP05060
DescriptionSecretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into- PE-11; GAWK peptide; CCB peptide]
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted Note=Neuroendocrine and endocrine secretory granules.
Developmental StageNA
SimilarityBelongs to the chromogranin/secretogranin protein family.
Tissue SpecificityExpressed in the adrenal medulla; and in pheochromocytoma. Not expressed in liver.
Post Translational ModificationExtensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues.
FunctionSecretogranin-1 is a neuroendocrine secretory granule protein; which may be the precursor for other biologically active peptides.
Length677
Molecular Weight78
NameSecretogranin-1
SequenceFLGEGHHRVQENQMDKARRHPQGAWKELDRNYLNYGEEGAPGKWQQQGDLQDTKENREEARFQDKQYSSHHTAE
Sequence map1776
PDB ID3608978; 14702039; 11780052; 15489334; 1882087; 7784254; 3970711; 3678488; 14997482; 168076
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA