| Primary information |
|---|
| ID | 12801 |
| Uniprot ID | P01160 |
| Description | Natriuretic peptides A (Atrial natriuretic factor prohormone) (proANF) (Atrial natriuretic peptide prohormone) (preproANP) (proANP) (Atriopeptigen) (Cardiodilatin) (CDD) (preproCDD-ANF) [Cleaved into- Long-acting natriuretic peptide (LANP) (Long-acting natriuretic hormone) (LANH) (Pro atrial natriur |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | [Long-acting natriuretic peptide]- Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the natriuretic peptide family. |
| Tissue Specificity | [Urodilatin]- Detected in the kidney distal tubular cells (at protein level) (PubMed-9794555; PubMed-8384600). Present in urine (at protein level) (PubMed-2972874; PubMed-9794555; PubMed-8351194; PubM |
| Post Translational Modification | The precursor molecule is proteolytically cleaved by CORIN at Arg-123 to produce atrial natriuretic peptide (PubMed-10880574; PubMed-14559895; PubMed-7984506). Undergoes further proteolytic cleavage b |
| Function | [Atrial natriuretic peptide]- Hormone that plays a key role in mediating cardio-renal homeostasis; and is involved in vascular remodeling and regulating energy metabolism |
| Length | 151 |
| Molecular Weight | 16 |
| Name | Natriuretic peptides A |
| Sequence | EVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQR |
| Sequence map | 888 |
| PDB ID | 6203042; 6547996; 6095118; 6095119; 6542248; 3158606; 16710414; 15489334; 6097248; 6238331; |
| Drugpedia | 1ANP;1YK0;3N57;7BRH;7BRJ;7BRK; |
| Receptor | P16066 |
| Domain | NA |
| Pharmaceutical Use | NA
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