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12710 details
Primary information
ID12710
Uniprot IDQ9TU09
DescriptionLeptin (Obesity factor) (Fragment)
OrganismEquus caballus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Perissodactyla (odd-toed ungulates); Equidae (horses); Equus; Equus; Equus caballus (Horse)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the leptin family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionKey player in the regulation of energy balance and body weight control. Once released into the circulation; has central and peripheral effects by binding LEPR; found in many tissues; which results in the activation of several major signaling pathways. In the hypothalamus; acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides; also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery; increases basal metabolism; influences reproductive function; regulates pancreatic beta-cell function and insulin secretion; is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus; activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequen
Length145
Molecular Weight15
NameLeptin
SequencePIRKVQDDTKTLIKTIVTRINDISHTQSVSSKQRVTGLDFIPGLHPVLSLSKMDQTLAIYQQILTSLPSRNVIQISNDLENLRDLLHLLASSKSCPLPQARGLETLASLGGVLEASLLLHRGGSPEQAAGVS
Sequence map15-25
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA