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12700 details
Primary information
ID12700
Uniprot IDP20607
DescriptionInterleukin-6 (IL-6)
OrganismRattus norvegicus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the IL-6 superfamily.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionCytokine with a wide variety of biological functions in immunity; tissue regeneration; and metabolism. Binds to IL6R; then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling'; whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively; 'cluster signaling' occurs when membrane-bound IL6-IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Length211
Molecular Weight24
NameInterleukin-6
SequencePTSQVRRGDFTEDTTHNRPVYTTSQVGGLITYVLREILEMRKELCNGNSDCMNSDDALSENNLKLPEIQRNDGCFQTGYNQEICLLKICSGLLEFRFYLEFVKNNLQDNKKDKARVIQSNTETLVHIFKQEIKDSYKIVLPTPTSNALLMEKLESQKEWLRTKTIQLILKALEEFLKVTMRSTRQT
Sequence map28-31
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA