Primary information |
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ID | 12700 |
Uniprot ID | P20607 |
Description | Interleukin-6 (IL-6) |
Organism | Rattus norvegicus |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat) |
Subcellular Location | Secreted |
Developmental Stage | NA |
Similarity | Belongs to the IL-6 superfamily. |
Tissue Specificity | NA |
Post Translational Modification | NA |
Function | Cytokine with a wide variety of biological functions in immunity; tissue regeneration; and metabolism. Binds to IL6R; then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling'; whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively; 'cluster signaling' occurs when membrane-bound IL6-IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. |
Length | 211 |
Molecular Weight | 24 |
Name | Interleukin-6 |
Sequence | PTSQVRRGDFTEDTTHNRPVYTTSQVGGLITYVLREILEMRKELCNGNSDCMNSDDALSENNLKLPEIQRNDGCFQTGYNQEICLLKICSGLLEFRFYLEFVKNNLQDNKKDKARVIQSNTETLVHIFKQEIKDSYKIVLPTPTSNALLMEKLESQKEWLRTKTIQLILKALEEFLKVTMRSTRQT |
Sequence map | 28-31 |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
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