| Primary information |
|---|
| ID | 12700 |
| Uniprot ID | P20607 |
| Description | Interleukin-6 (IL-6) |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the IL-6 superfamily. |
| Tissue Specificity | NA |
| Post Translational Modification | NA |
| Function | Cytokine with a wide variety of biological functions in immunity; tissue regeneration; and metabolism. Binds to IL6R; then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling'; whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively; 'cluster signaling' occurs when membrane-bound IL6-IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. |
| Length | 211 |
| Molecular Weight | 24 |
| Name | Interleukin-6 |
| Sequence | PTSQVRRGDFTEDTTHNRPVYTTSQVGGLITYVLREILEMRKELCNGNSDCMNSDDALSENNLKLPEIQRNDGCFQTGYNQEICLLKICSGLLEFRFYLEFVKNNLQDNKKDKARVIQSNTETLVHIFKQEIKDSYKIVLPTPTSNALLMEKLESQKEWLRTKTIQLILKALEEFLKVTMRSTRQT |
| Sequence map | 28-31 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|