| Primary information |
|---|
| ID | 12699 |
| Uniprot ID | P08505 |
| Description | Interleukin-6 (IL-6) (B-cell hybridoma growth factor) (Interleukin HP-1) |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the IL-6 superfamily. |
| Tissue Specificity | Expressed by dendritic cells and macrophages (PubMed-27893700; PubMed-23045607). Expressed by activated follicular B cells (PubMed-23045607). Abundantly expressed in the central nervous system (CNS); |
| Post Translational Modification | N- and O-glycosylated. |
| Function | Cytokine with a wide variety of biological functions in immunity; tissue regeneration; and metabolism (Probable). Binds to IL6R; then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway |
| Length | 211 |
| Molecular Weight | 24 |
| Name | Interleukin-6 |
| Sequence | PTSQVRRGDFTEDTTPNRPVYTTSQVGGLITHVLWEIVEMRKELCNGNSDCMNNDDALAENNLKLPEIQRNDGCYQTGYNQEICLLKISSGLLEYHSYLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDLHKIVLPTPISNALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQT |
| Sequence map | 28-31 |
| PDB ID | 2L3Y; |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|