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12699 details
Primary information
ID12699
Uniprot IDP08505
DescriptionInterleukin-6 (IL-6) (B-cell hybridoma growth factor) (Interleukin HP-1)
OrganismMus musculus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the IL-6 superfamily.
Tissue SpecificityExpressed by dendritic cells and macrophages (PubMed-27893700; PubMed-23045607). Expressed by activated follicular B cells (PubMed-23045607). Abundantly expressed in the central nervous system (CNS);
Post Translational ModificationN- and O-glycosylated.
FunctionCytokine with a wide variety of biological functions in immunity; tissue regeneration; and metabolism (Probable). Binds to IL6R; then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway
Length211
Molecular Weight24
NameInterleukin-6
SequencePTSQVRRGDFTEDTTPNRPVYTTSQVGGLITHVLWEIVEMRKELCNGNSDCMNNDDALAENNLKLPEIQRNDGCYQTGYNQEICLLKISSGLLEYHSYLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDLHKIVLPTPISNALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQT
Sequence map28-31
PDB ID2L3Y;
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA