| Primary information |
|---|
| ID | 12670 |
| Uniprot ID | D4AB34 |
| Description | Erythroferrone (Complement C1q tumor necrosis factor-related protein 15) (Myonectin) |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the adipolin/erythroferrone family. |
| Tissue Specificity | NA |
| Post Translational Modification | N-glycosylated. |
| Function | Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage- produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver; thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. |
| Length | 341 |
| Molecular Weight | 36 |
| Name | Erythroferrone |
| Sequence | GVPESAEPVGTQARPQPPGTELPAPPAHSPPEPTIAHAHSVDPRDAWMLFVKQSDKGINSKKRSRTKARRLKLGLPGPPGPPGPQGPPGPFIPSEVLLKEFQLLLKGAVRQRESTEHCTRDLTTPASGGPSRDPVTQELESQDQGAVLALLAATLAQSPRAPRVEAAFHCRLRRDVQVERRALHELGVYYLPEVEGAFRRGPGLNLTSGQYTAPVAGFYALAATLHVALTKQPRKGPPQPRDRLRLLICIQSLCQHNASLETVMGLENSSELFTISVNGVLYLQTGHYTSVFLDNASGSSLTVRGGSHFSAILLGL |
| Sequence map | 30-41 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|