| Primary information |
|---|
| ID | 12663 |
| Uniprot ID | Q9N2I2 |
| Description | Plasma serine protease inhibitor (Protein C inhibitor) (PCI) (Serpin A5) |
| Organism | Bos taurus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos (oxen; cattle); Bos taurus (Bovine) |
| Subcellular Location | Secreted; extracellular space |
| Developmental Stage | NA |
| Similarity | Belongs to the serpin family. |
| Tissue Specificity | Expressed strongly in the liver; and moderately in the kidney and testis; but not in other tissues tested. |
| Post Translational Modification | N-glycosylated; glycans consist of a mixture of sialylated bi- (including sialyl-Lewis X epitopes); tri- and tetra-antennary complex-type chains; affects the maximal heparin- and thrombomodulin-enhanc |
| Function | Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin; factor XI; factor Xa; plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma; inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue- and urinary-type plasminogen activato |
| Length | 404 |
| Molecular Weight | 45 |
| Name | Plasma serine protease inhibitor |
| Sequence | KIQEVPPAVTTAPPGSRDFVFDLYRALAAAAPAQNIFFSPLSITVSLAMLSLGAQSNTKAQILEGLGIGPGEGSEEELHSASQRLLRELQQPQDSLQLSLGNALFTKPRLPIQEAFLGAMRTLYLADTFPTNFEDPEGAKKKINDYVAKQTKGKIVDLIKSLDGTQVMVMVNYIFFKAKWETSFNLKSTHEQDFYVTPETVVRVPMMKQQDQFYYLLDRNLSCKVVGVPYQGNATAFFILPREGEMEQVENGLKEKTLKKWLRMPMKRRLELYLPKFSIEGSYQLEEVLPKLGIRDIFTSDADLTGISNHSSIRVSEMVHKAVVEVDESGTQAAAATGMVITFKSARLGSQRIVFNRPFLVLIVKNSKHILFLGKVTRP |
| Sequence map | 31-44 |
| PDB ID | 3B9F; |
| Drugpedia | NA |
| Receptor | NA |
| Domain | The reactive center loop (RCL) extends out from th |
| Pharmaceutical Use | NA
|