Detailed description page of Hmrbase2

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12662 details
Primary information
ID12662
Uniprot IDO77755
DescriptionInhibin alpha chain
OrganismTrichosurus vulpecula
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Metatheria; Diprotodontia; Phalangeridae (possums and cuscuses); Trichosurus (brush-tailed possums); Trichosurus vulpecula (Brush-tailed possum)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the TGF-beta family.
Tissue SpecificityNA
Post Translational ModificationProteolytic processing yields a number of bioactive forms; consisting either solely of the mature alpha chain; of the most N-terminal propeptide linked through a disulfide bond to the mature alpha cha
FunctionInhibins and activins inhibit and activate; respectively; the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion; gonadal hormone secretion; germ cell development and maturation; erythroid differentiation; insulin secretion; nerve cell survival; embryonic axial development or bone growth; depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Length361
Molecular Weight38
NameInhibin alpha chain
SequencePLPPPWPWSPAALRLLQRPSEDPAAHADCHRAALNISFQELGWDQWIVHPPSFIFHYCHGGCGLVPSPVLSPGAALTPSQPLPLGPGSRPCCAAMPSTMRPLRVRTTSDGGYSFKYEIVPNLLTQHCACI
Sequence map237-01
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA