Primary information |
---|
ID | 12662 |
Uniprot ID | O77755 |
Description | Inhibin alpha chain |
Organism | Trichosurus vulpecula |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Metatheria; Diprotodontia; Phalangeridae (possums and cuscuses); Trichosurus (brush-tailed possums); Trichosurus vulpecula (Brush-tailed possum) |
Subcellular Location | Secreted |
Developmental Stage | NA |
Similarity | Belongs to the TGF-beta family. |
Tissue Specificity | NA |
Post Translational Modification | Proteolytic processing yields a number of bioactive forms; consisting either solely of the mature alpha chain; of the most N-terminal propeptide linked through a disulfide bond to the mature alpha cha |
Function | Inhibins and activins inhibit and activate; respectively; the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion; gonadal hormone secretion; germ cell development and maturation; erythroid differentiation; insulin secretion; nerve cell survival; embryonic axial development or bone growth; depending on their subunit composition. Inhibins appear to oppose the functions of activins. |
Length | 361 |
Molecular Weight | 38 |
Name | Inhibin alpha chain |
Sequence | PLPPPWPWSPAALRLLQRPSEDPAAHADCHRAALNISFQELGWDQWIVHPPSFIFHYCHGGCGLVPSPVLSPGAALTPSQPLPLGPGSRPCCAAMPSTMRPLRVRTTSDGGYSFKYEIVPNLLTQHCACI |
Sequence map | 237-01 |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
|