Detailed description page of Hmrbase2

This page displays user query in tabular form.

12653 details
Primary information
ID12653
Uniprot IDG7PWZ3
DescriptionGrowth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1)
OrganismMacaca fascicularis
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae (Old World monkeys); Cercopithecinae; Macaca (macaques); Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the TGF-beta family.
Tissue SpecificityDetected in plasma (at protein level).
Post Translational ModificationNA
FunctionRegulates food intake; energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor; GFRAL; and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala; which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions
Length308
Molecular Weight34
NameGrowth/differentiation factor 15
SequenceRARARNGDRCPLGPGRCCRLHTVHASLEDLGWADWVLSPREVQVTMCIGACPSQFREANMHAQIKMNLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCHCV
Sequence map198-08
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA