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12643 details
Primary information
ID12643
Uniprot IDQ06826
DescriptionBone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
OrganismRattus norvegicus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat)
Subcellular LocationSecreted; extracellular space; extracellular matrix.
Developmental StageNA
SimilarityBelongs to the TGF-beta family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionGrowth factor of the TGF-beta superfamily that plays essential roles in many developmental processes; including neurogenesis; vascular development; angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface; BMPR2 phosphorylates and activates BMPR1A. In turn; BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase; PI3K/Akt; or SRC cascades. For example; induces SRC phosphorylation which; in turn; activates VEGFR2; leading to an angiogenic response.
Length408
Molecular Weight46
NameBone morphogenetic protein 4
SequencePKHHPQRSRKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
Sequence map299-48
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA