| Primary information |
|---|
| ID | 12618 |
| Uniprot ID | P09038 |
| Description | Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the heparin-binding growth factors family. |
| Tissue Specificity | Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells; but not in non-cancerous liver tissue. |
| Post Translational Modification | Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion. |
| Function | Acts as a ligand for FGFR1; FGFR2; FGFR3 and FGFR4 |
| Length | 288 |
| Molecular Weight | 30 |
| Name | Fibroblast growth factor 2 |
| Sequence | ALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS |
| Sequence map | 147-48 |
| PDB ID | 1BAS; 1BFB; 1BFC; 1BFF; 1BFG; 1BLA; 1BLD; 1CVS; 1EV2; 1FGA; 1FQ9; 1II4; 1IIL; 2BFH; 2FGF; 2M49; 4FGF |
| Drugpedia | DB03981;DB03935;DB05434;DB01109;DB03959;DB00686;DB |
| Receptor | Q92896; P22455; Q8N441 |
| Domain | NA |
| Pharmaceutical Use | NA
|