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12594 details
Primary information
ID12594
Uniprot IDP84809
DescriptionLipolysis-activating peptide 1-beta chain (BotLVP1-beta) (LVP1-beta)
OrganismButhus occitanus tunetanus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Buthus; Buthus occitanus (Common European scorpion); Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the long (3 C-C) scorpion toxin superfamily.
Tissue SpecificityExpressed by the venom gland.
Post Translational ModificationNA
FunctionThe homodimer inhibits HMG-CoA reductase (HMGCR) (32% of inhibition produced by 0.6 uM); a glycoprotein involved in the control of cholesterol biosynthesis. The inhibitory effects of bumarsin are seen at much lower concentrations (0.6 uM) than that for statins such as atorvastatin (5 mM) and simvastatin (10 uM). In addition to inhibition of HMG-CoA reductase; this protein lowers cholesterol levels by inducing steroid hormone synthesis via StAR; and by increasing reverse cholesterol transport mediated by the induction of ABCA1 and APOA1.
Length95
Molecular Weight10
NameLipolysis-activating peptide 1-beta chain
SequenceNVFPNRELGILYGCKGYGNAFCDKVCKMHLARGGGRCGEPNPVMWACECIDIDEDNGYFLNALEKQCPLLKG
Sequence map24-35
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA