| Primary information |
|---|
| ID | 12588 |
| Uniprot ID | Q8IVG9 |
| Description | Humanin (Humanin mitochondrial) (HNM) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | Levels decline with increasing age. |
| Similarity | Belongs to the humanin family. |
| Tissue Specificity | Expressed in testis; seminal plasma and sperm (at protein level) (PubMed-20542501; PubMed-30920769). Higher seminal plasma levels are associated with normospermia than with oligospermia; asthenospermi |
| Post Translational Modification | NA |
| Function | Plays a role as a neuroprotective factor |
| Length | 24 |
| Molecular Weight | 2 |
| Name | Humanin |
| Sequence | APRGFSCLLLLTSEIDLPVKRRA |
| Sequence map | 1-24 |
| PDB ID | 1Y32; 2GD3; 5GIW; |
| Drugpedia | NA |
| Receptor | P25090 |
| Domain | Largely unstructured in aqueous solution. |
| Pharmaceutical Use | NA
|