| Primary information |
|---|
| ID | 12563 |
| Uniprot ID | P12843 |
| Description | Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2) (BRL-BP) |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat) |
| Subcellular Location | Secreted |
| Developmental Stage | Predominantly expressed at fetal stages with highest expression in fetal liver. Also expressed in fetal kidney; intestine and lung; as well as muscle; heart and stomach. |
| Similarity | NA |
| Tissue Specificity | In adults; expressed in brain; testes; ovaries; and kidney. Expression in the adult liver is barely detectable. |
| Post Translational Modification | O-glycosylated. |
| Function | Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
| Length | 304 |
| Molecular Weight | 32 |
| Name | Insulin-like growth factor-binding protein 2 |
| Sequence | VLFRCPPCTPERLAACGPPPDAPCAELVREPGCGCCSVCARQEGEACGVYIPRCAQTLRCYPNPGSELPLKALVTGAGTCEKRRVGATPQQVADSEDDHSEGGLVENHVDGTMNMLGGSSAGRKPPKSGMKELAVFREKVNEQHRQMGKGAKHLSLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDDRGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKPIQGAPTIRGDPECHLFYNEQQENDGAHAQRVQ |
| Sequence map | 40-04 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | The C-terminus is required for IGF-binding and gro |
| Pharmaceutical Use | NA
|