| Primary information |
|---|
| ID | 12562 |
| Uniprot ID | P47877 |
| Description | Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2) (mIGFBP-2) |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse) |
| Subcellular Location | Secreted |
| Developmental Stage | Expressed embryos at day 11.5. Also expressed in fetal livers with expression increasing dramatically after birth. Expression decreases only slightly after postnatal day 3 and remains abundant thereaf |
| Similarity | NA |
| Tissue Specificity | Highly expressed in adult liver; but also in kidney; lung; brain; spleen; testis and ovary. |
| Post Translational Modification | O-glycosylated. |
| Function | Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
| Length | 305 |
| Molecular Weight | 32 |
| Name | Insulin-like growth factor-binding protein 2 |
| Sequence | VLFRCPPCTPERLAACGPPPDAPCAELVREPGCGCCSVCARQEGEACGVYIPRCAQTLRCYPNPGSELPLKALVTGAGTCEKRRVGTTPQQVADSDDDHSEGGLVENHVDGTMNMLGGGSSAGRKPLKSGMKELAVFREKVNEQHRQMGKGAKHLSLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDDRGPLEHLYSLHIPNCDKHGRYNLKQCKMSLNGQRGECWCVNPNTGKPIQGAPTIRGDPECHLFYNEQQETGGAHAQSVQ |
| Sequence map | 40-05 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | The C-terminus is required for IGF-binding and gro |
| Pharmaceutical Use | NA
|