Detailed description page of Hmrbase2

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12533 details
Primary information
ID12533
Uniprot IDP26583
DescriptionHigh mobility group protein B2 (High mobility group protein 2) (HMG-2)
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationNucleus
Developmental StageNA
SimilarityBelongs to the HMGB family.
Tissue SpecificityExpressed in gastric and intestinal tissues (at protein level).
Post Translational ModificationReduction/oxidation of cysteine residues Cys-23; Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional
FunctionMultifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription; chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity
Length209
Molecular Weight24
NameHigh mobility group protein B2
SequenceGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE
Sequence map4-29
PDB IDNA
DrugpediaNA
ReceptorNA
DomainBoth; HMG box 1 and HMG box 2; show antimicrobial
Pharmaceutical UseNA