| Primary information |
|---|
| ID | 12526 |
| Uniprot ID | P18406 |
| Description | CCN family member 1 (3CH61) (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse) |
| Subcellular Location | Secreted |
| Developmental Stage | Expressed from G(0)/G(1) through mid-G(1) in normal cells; and at a constant level in rapidly growing cells. |
| Similarity | Belongs to the CCN family. |
| Tissue Specificity | Low in kidney; adrenal gland; testes; brain; and ovary; moderate in heart; uterus; and skeletal muscle; highest in lung. |
| Post Translational Modification | NA |
| Function | Promotes cell proliferation; chemotaxis; angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating; in skin fibroblasts; the expression of a number of genes involved in angiogenesis; inflammation and matrix remodeling including VEGA-A; VEGA-C; MMP1; MMP3; TIMP1; uPA; PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1; cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3. |
| Length | 379 |
| Molecular Weight | 41 |
| Name | CCN family member 1 |
| Sequence | CPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVSGQCCEEWVCDEDSIKDSLDDQDDLLGLDASEVELTRNNELIAIGKGSSLKRLPVFGTEPRVLFNPLHAHGQKCIVQTTSWSQCSKSCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCSSVKKYRPKYCGSCVDGRCCTPLQTRTVKMRFRCEDGEMFSKNVMMIQSCKCNYNCPHPNEASFRLYSLFNDIHKFRD |
| Sequence map | 31-19 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|