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12522 details
Primary information
ID12522
Uniprot IDP28686
DescriptionCCN family member 3 (Cellular communication network factor 3) (Nephroblastoma-overexpressed gene protein) (Protein NOV)
OrganismGallus gallus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria (diapsids); Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae (turkeys); Phasianinae; Gallus; Gallus gallus (Chicken)
Subcellular LocationSecreted
Developmental StageMAV1-induced nephroblastomas express a high level of NOV gene whose transcription is normally arrested in adult kidney.
SimilarityBelongs to the CCN family.
Tissue SpecificityBrain and heart; and at a lower level in muscle and intestine; in the embryo. Lung and less so in brain and spleen; in adult chicken.
Post Translational ModificationNA
FunctionImmediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of CCN3 gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro.
Length351
Molecular Weight38
NameCCN family member 3
SequenceGREAACPRPCGGRCPAEPPRCAPGVPAVLDGCGCCLVCARQRGESCSPLLPCDESGGLYCDRGPEDGGGAGICMVLEGDNCVFDGMIYRNGETFQPSCKYQCTCRDGQIGCLPRCNLGLLLPGPDCPFPRKIEVPGECCEKWVCDPRDEVLLGGFAMAAYRQEATLGIDVSDSSANCIEQTTEWSACSKSCGMGFSTRVTNRNQQCEMVKQTRLCMMRPCENEEPSDKKGKKCIQTKKSMKAVRFEYKNCTSVQTYKPRYCGLCNDGRCCTPHNTKTIQVEFRCPQGKFLKKPMMLINTCVCHGNCPQSNNAFFQPLDPMSSEAKI
Sequence map30-51
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA