Primary information |
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ID | 12516 |
Uniprot ID | P10107 |
Description | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) |
Organism | Mus musculus |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse) |
Subcellular Location | Nucleus |
Developmental Stage | NA |
Similarity | Belongs to the annexin family. |
Tissue Specificity | Detected in lung (PubMed-12475898; PubMed-17384087). Detected at the apical membrane of airway epithelial cells (PubMed-17384087). Detected in intestinal epithelial cells (PubMed-18802107). Detected i |
Post Translational Modification | Phosphorylated by protein kinase C; EGFR and TRPM7. Phosphorylated in response to EGF treatment. |
Function | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity |
Length | 346 |
Molecular Weight | 38 |
Name | Annexin A1 |
Sequence | MVSEFLKQARFLENQEQEYVQAVKSYKGGPGSAVSPYPSFNVSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQENGKPLDEVLRKALTGHLEEVVLAMLKTPAQFDADELRGAMKGLGTDEDTLIEILTTRSNEQIREINRVYREELKRDLAKDITSDTSGDFRKALLALAKGDRCQDLSVNQDLADTDARALYEAGERRKGTDVNVFTTILTSRSFPHLRRVFQNYGKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKALIRIMVSRSEIDMNEIKVFYQKKYGISLCQAILDETKGDYEKILVALCGGN |
Sequence map | 7-46 |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | The full-length protein can bind eight Ca(2+) ions |
Pharmaceutical Use | NA
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