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12516 details
Primary information
ID12516
Uniprot IDP10107
DescriptionAnnexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35)
OrganismMus musculus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse)
Subcellular LocationNucleus
Developmental StageNA
SimilarityBelongs to the annexin family.
Tissue SpecificityDetected in lung (PubMed-12475898; PubMed-17384087). Detected at the apical membrane of airway epithelial cells (PubMed-17384087). Detected in intestinal epithelial cells (PubMed-18802107). Detected i
Post Translational ModificationPhosphorylated by protein kinase C; EGFR and TRPM7. Phosphorylated in response to EGF treatment.
FunctionPlays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity
Length346
Molecular Weight38
NameAnnexin A1
SequenceMVSEFLKQARFLENQEQEYVQAVKSYKGGPGSAVSPYPSFNVSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQENGKPLDEVLRKALTGHLEEVVLAMLKTPAQFDADELRGAMKGLGTDEDTLIEILTTRSNEQIREINRVYREELKRDLAKDITSDTSGDFRKALLALAKGDRCQDLSVNQDLADTDARALYEAGERRKGTDVNVFTTILTSRSFPHLRRVFQNYGKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKALIRIMVSRSEIDMNEIKVFYQKKYGISLCQAILDETKGDYEKILVALCGGN
Sequence map7-46
PDB IDNA
DrugpediaNA
ReceptorNA
DomainThe full-length protein can bind eight Ca(2+) ions
Pharmaceutical UseNA