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12501 details
Primary information
ID12501
Uniprot IDQ03288
DescriptionAgouti-signaling protein (ASP) (Agouti coat color protein) (Agouti switch protein)
OrganismMus musculus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse)
Subcellular LocationSecreted
Developmental StageWidely expressed in embryonic and neonatal skin.
SimilarityNA
Tissue SpecificityEpithelial cells of the hair follicles and the epidermis.
Post Translational ModificationNA
FunctionInvolved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP; leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth.
Length131
Molecular Weight14
NameAgouti-signaling protein
SequenceLALEETLGDDRSLRSNSSMNSLDFSSVSIVALNKKSKKISRKEAEKRKRSSKKKASMKKVARPPPPSPCVATRDSCKPPAPACCDPCASCQCRFFGSACTCRVLNPNC
Sequence map25-11
PDB IDNA
DrugpediaNA
ReceptorNA
DomainThe presence of a 'disulfide through disulfide kno
Pharmaceutical UseNA