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12499 details
Primary information
ID12499
Uniprot IDQ6UXH0
DescriptionAngiopoietin-like protein 8 (Betatrophin) (Lipasin) (Refeeding-induced fat and liver protein)
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted
Developmental StageTranscripts are up-regulated by 100 fold during adipogenesis.
SimilarityBelongs to the ANGPTL8 family.
Tissue SpecificityPredominantly expressed in liver. Also expressed in adipose tissues.
Post Translational ModificationProteolytically cleaved at the N-terminus.
FunctionHormone that acts as a blood lipid regulator by regulating serum triglyceride levels
Length198
Molecular Weight22
NameAngiopoietin-like protein 8
SequencePMGGPELAQHEELTLLFHGTLQLGQALNGVYRTTEGRLTKARNSLGLYGRTIELLGQEVSRGRDAAQELRASLLETQMEEDILQLQAEATAEVLGEVAQAQKVLRDSVQRLEVQLRSAWLGPAYREFEVLKAHADKQSHILWALTGHVQRQRREMVAQQHRLRQIQERLHTAALPA
Sequence map25-18
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA