| Primary information |
|---|
| ID | 12498 |
| Uniprot ID | P04083 |
| Description | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Nucleus |
| Developmental Stage | NA |
| Similarity | Belongs to the annexin family. |
| Tissue Specificity | Detected in resting neutrophils (PubMed-10772777). Detected in peripheral blood T-cells (PubMed-17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disea |
| Post Translational Modification | Phosphorylated by protein kinase C; EGFR and TRPM7 (PubMed-2457390; PubMed-15485879). Phosphorylated in response to EGF treatment (PubMed-2532504). |
| Function | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity |
| Length | 346 |
| Molecular Weight | 38 |
| Name | Annexin A1 |
| Sequence | MVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNALLSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKYTKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIMVSRSEIDMNDIKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN |
| Sequence map | 7-46 |
| PDB ID | 1AIN; 1BO9; 1QLS; 5VFW; |
| Drugpedia | DB00288;DB14669;DB01222;DB01013;DB01234;DB14649;DB |
| Receptor | P25090 |
| Domain | The full-length protein can bind eight Ca(2+) ions |
| Pharmaceutical Use | Peptides based on the N-terminal sequence might be used for the treatment of inflammation; e.g. in chronic bowel diseases and in rheumatoid arthritis.
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