| Primary information |
|---|
| ID | 12471 |
| Uniprot ID | P08185 |
| Description | Corticosteroid-binding globulin (CBG) (Serpin A6) (Transcortin) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the serpin family. |
| Tissue Specificity | Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells. |
| Post Translational Modification | N-glycosylated; binds 5 oligosaccharide chains.; Glycosylation in position Asn-260 is needed for steroid binding. |
| Function | Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. |
| Length | 405 |
| Molecular Weight | 45 |
| Name | Corticosteroid-binding globulin |
| Sequence | DPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV |
| Sequence map | 29-45 |
| PDB ID | 2VDX; 2VDY; 4BB2; 4C41; 4C49; |
| Drugpedia | DB00240;DB00394;DB00443;DB14669;DB01222;DB01410;DB |
| Receptor | NA |
| Domain | Proteolytic cleavage leads to an important conform |
| Pharmaceutical Use | NA
|