| Primary information |
|---|
| ID | 12470 |
| Uniprot ID | P12643 |
| Description | Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the TGF-beta family. |
| Tissue Specificity | Particularly abundant in lung; spleen and colon and in low but significant levels in heart; brain; placenta; liver; skeletal muscle; kidney; pancreas; prostate; ovary and small intestine. |
| Post Translational Modification | NA |
| Function | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes; including cardiogenesis; neurogenesis; and osteogenesis |
| Length | 396 |
| Molecular Weight | 44 |
| Name | Bone morphogenetic protein 2 |
| Sequence | AKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR |
| Sequence map | 289-36 |
| PDB ID | 1ES7; 1REU; 1REW; 2GOO; 2H62; 2H64; 2QJ9; 2QJA; 2QJB; 3BK3; 3BMP; 4MID; 4N1D; 4UHY; 4UHZ; 4UI0; 4UI1 |
| Drugpedia | NA |
| Receptor | P36894; Q13873 |
| Domain | NA |
| Pharmaceutical Use | Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft fractures.
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