Primary information |
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ID | 12449 |
Uniprot ID | P31515 |
Description | Follistatin (FS) (Activin-binding protein) (XFS-319) |
Organism | Xenopus laevis |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus; Xenopus laevis (African clawed frog) |
Subcellular Location | Secreted |
Developmental Stage | The short isoform is present maternally while the long isoform is expressed at gastrula stages. Detected in a few cells of the Spemann organizer at the onset of gastrulation. During gastrulation expre |
Similarity | NA |
Tissue Specificity | Spemann organizer and notochord. |
Post Translational Modification | NA |
Function | Binds directly to activin and functions as an activin antagonist which plays a role in neural induction. The short isoform is a more potent inhibitor of activin than the long isoform. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). |
Length | 341 |
Molecular Weight | 37 |
Name | Follistatin |
Sequence | NCWLQQSKNGRCQVLYRTELSKEECCKTGRLGTSWTEEDVPNSTLFKWMIFHGGAPHCIPCKETCENVDCGPGKKCKMNKKNKPRCVCAPDCSNITWKGSVCGIDGKTYKDECALLKAKCKGVPELDVQYQGKCKKTCRDVLCPGSSSCVVDQTNNAYCVTCNRICPEPTSPDQYLCGNDGITYGSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCSAGKKCLWDSRVGRGRCALCDDLCGESKSDDTVCASDNTTYPSECAMKQAACSTGILLEVKHSGSCNSIVEDTEEEEEEEEPDYSFVISSW |
Sequence map | 35-41 |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
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