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12449 details
Primary information
ID12449
Uniprot IDP31515
DescriptionFollistatin (FS) (Activin-binding protein) (XFS-319)
OrganismXenopus laevis
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus; Xenopus laevis (African clawed frog)
Subcellular LocationSecreted
Developmental StageThe short isoform is present maternally while the long isoform is expressed at gastrula stages. Detected in a few cells of the Spemann organizer at the onset of gastrulation. During gastrulation expre
SimilarityNA
Tissue SpecificitySpemann organizer and notochord.
Post Translational ModificationNA
FunctionBinds directly to activin and functions as an activin antagonist which plays a role in neural induction. The short isoform is a more potent inhibitor of activin than the long isoform. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
Length341
Molecular Weight37
NameFollistatin
SequenceNCWLQQSKNGRCQVLYRTELSKEECCKTGRLGTSWTEEDVPNSTLFKWMIFHGGAPHCIPCKETCENVDCGPGKKCKMNKKNKPRCVCAPDCSNITWKGSVCGIDGKTYKDECALLKAKCKGVPELDVQYQGKCKKTCRDVLCPGSSSCVVDQTNNAYCVTCNRICPEPTSPDQYLCGNDGITYGSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCSAGKKCLWDSRVGRGRCALCDDLCGESKSDDTVCASDNTTYPSECAMKQAACSTGILLEVKHSGSCNSIVEDTEEEEEEEEPDYSFVISSW
Sequence map35-41
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA