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12441 details
Primary information
ID12441
Uniprot IDP49157
DescriptionErythropoietin
OrganismSus scrofa
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Suina; Suidae (pigs); Sus; Sus scrofa (Pig)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the EPO/TPO family.
Tissue SpecificityProduced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
Post Translational ModificationNA
FunctionHormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors; including STAT1 and STAT3.
Length194
Molecular Weight21
NameErythropoietin
SequencePPRLICDSRVLERYILEAKEGENATMGCAESCSFSENITVPDTKVNFYAWKRMEVQQQAMEVWQGLALLSEAILQGQALLANSSQPSEALQLHVDKAVSGLRSLTSLLRALGAQKEAIPLPDASPSSATPLRTFAVDTLCKLFRNYSNFLRGKLTLYTGEACRRRDR
Sequence map30-14
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA