Primary information |
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ID | 12436 |
Uniprot ID | Q6H8T1 |
Description | Erythropoietin |
Organism | Spalax carmeli |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Spalacidae; Spalacinae (blind mole-rats); Spalax; Spalax carmeli (Southern Israeli blind subterranean mole rat) |
Subcellular Location | Secreted |
Developmental Stage | NA |
Similarity | Belongs to the EPO/TPO family. |
Tissue Specificity | NA |
Post Translational Modification | NA |
Function | Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors; including STAT1 and STAT3. |
Length | 192 |
Molecular Weight | 21 |
Name | Erythropoietin |
Sequence | PPRLICDSRVLERYILEAKEAENITMGCAEGPRFNENFTVPDTKVNFYAWKTMGVEEQAVEVWQGLSLLFEAILRAQAVLANSSQPSEMLQLHVDKAISGLRSLTSLLRALGAQKEAISPPDTTQVIPLRRFTVDTFCKLFRIYSNFLRGKLKLYTGEACRRGDR |
Sequence map | 30-12 |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
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