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12436 details
Primary information
ID12436
Uniprot IDQ6H8T1
DescriptionErythropoietin
OrganismSpalax carmeli
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Spalacidae; Spalacinae (blind mole-rats); Spalax; Spalax carmeli (Southern Israeli blind subterranean mole rat)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the EPO/TPO family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionHormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors; including STAT1 and STAT3.
Length192
Molecular Weight21
NameErythropoietin
SequencePPRLICDSRVLERYILEAKEAENITMGCAEGPRFNENFTVPDTKVNFYAWKTMGVEEQAVEVWQGLSLLFEAILRAQAVLANSSQPSEMLQLHVDKAISGLRSLTSLLRALGAQKEAISPPDTTQVIPLRRFTVDTFCKLFRIYSNFLRGKLKLYTGEACRRGDR
Sequence map30-12
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA