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12422 details
Primary information
ID12422
Uniprot IDP48798
DescriptionFibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)
OrganismMonodelphis domestica
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Metatheria; Didelphimorphia; Didelphidae (opossums); Didelphinae; Monodelphis (short-tailed opossums); Monodelphis domestica (Gray short-tailed opossum)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the heparin-binding growth factors family.
Tissue SpecificityNA
Post Translational ModificationPhosphorylation at Tyr-83 regulates FGF2 unconventional secretion.
FunctionActs as a ligand for FGFR1; FGFR2; FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV-ITGB3. Plays an important role in the regulation of cell survival; cell division; cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation.
Length156
Molecular Weight17
NameFibroblast growth factor 2
SequenceALSGDGGGGGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGIREKSDPNIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLALKYVTEECFFFERLESNNYNTYRSRKYSNWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Sequence map12-36
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA