Primary information |
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ID | 12422 |
Uniprot ID | P48798 |
Description | Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) |
Organism | Monodelphis domestica |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Metatheria; Didelphimorphia; Didelphidae (opossums); Didelphinae; Monodelphis (short-tailed opossums); Monodelphis domestica (Gray short-tailed opossum) |
Subcellular Location | Secreted |
Developmental Stage | NA |
Similarity | Belongs to the heparin-binding growth factors family. |
Tissue Specificity | NA |
Post Translational Modification | Phosphorylation at Tyr-83 regulates FGF2 unconventional secretion. |
Function | Acts as a ligand for FGFR1; FGFR2; FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV-ITGB3. Plays an important role in the regulation of cell survival; cell division; cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation. |
Length | 156 |
Molecular Weight | 17 |
Name | Fibroblast growth factor 2 |
Sequence | ALSGDGGGGGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGIREKSDPNIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLALKYVTEECFFFERLESNNYNTYRSRKYSNWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS |
Sequence map | 12-36 |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
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